Ball screws, with their micron-level transmission accuracy, low friction coefficient, high repeatability, and stable dynamic response, perfectly meet the stringent requirements of precision instruments and measurement equipment for "micro-displacement control," "zero transmission backlash," and "low vibration and noise." They have become the core component enabling high-precision linear motion in such equipment. The following are specific application scenarios and technical details.
Coordinate Measuring Machines (CMMs) serve as the "gold standard" for inspecting three-dimensional part dimensions (such as hole diameters, profile tolerances, and positional tolerances) in the industrial sector. Measurement errors must be controlled within 0.0005–0.005 mm, and the performance of ball screws directly determines the accuracy of the measurement results.
Application Location:Ball screws are integrated into the X/Y/Z-axis stage transmission system of CMMs, driving measurement probes (such as touch-trigger probes and laser scanners) to perform linear scans or point sampling along the part surface.
Typical Case:When inspecting the hole diameter tolerance of an automotive engine block (requiring ±0.002 mm), the CMM drives the probe along the hole axis via ball screws to move at a constant linear speed, collecting diameter data in real time. To ensure reliable inspection results, the transmission error must be controlled within 0.0003 mm.

The photolithography machine is the "crown jewel" of semiconductor manufacturing. Its wafer stage must position the wafer and photomask with alignment accuracy within 10 nm. The application of ball screws meets two core requirements:
Wafer dicing divides an entire wafer into dozens or even hundreds of dies. The cutting street width is only 50–100 μm, and the cutting depth error must be ≤5 μm to avoid damaging the internal circuitry:
Application Location:Ball screws drives are used in both the cutting head's feed system (equipped with a diamond blade) and the wafer stage's translation system.
Core Functions:

Application Location:Auxiliary displacement stage of the laser galvanometer (or workpiece stage).
Core Functions:
A laser interferometer is the "precision benchmark" for calibrating CNC machine tools and coordinate measuring machines (CMMs). Its own displacement measurement precision must reach 0.1 μm/m, and the application of ball screws needs to meet the requirement of "error-free transmission":
Application Location:Movable mirror bracket of the interferometer.
Core Function:The ball screw drives the mirror to move uniformly and linearly along the laser optical path. The movement is free of vibration and yaw, ensuring stable laser interference signals. This enables accurate measurement of the displacement error of the calibrated equipment (e.g., when calibrating the positioning error of a CNC machine tool, the interferometer compares the actual displacement of the machine tool with the standard displacement of the ball screw to obtain the error value).
Gene sequencing requires mixing DNA samples with reagents in specific proportions. The reagent dosage is only 1–10 μL, and the pushing precision must be ≤ 0.1 μL—otherwise, the accuracy of sequencing data will be affected:
Application Location:Drive system for the plunger of reagent syringes.
Core Function:Ball screws drive the syringe plunger to achieve 0.01 mm-level micro-feeding, precisely controlling the volume of reagents pushed. Meanwhile, the sealed design of ball screws (equipped with dust covers and sealing rings) prevents lubricant leakage from contaminating reagents, meeting the sterile requirements of biomedical applications.
In flow cytometers (cell sorters), individual cells need to be separated from cell suspensions, with a sorting precision of 5–10 μm (equivalent to 1–2 times the diameter of a cell):
Application Location:Fine-tuning displacement stage for the sorting nozzle.
Core Function:Ball screws drive the nozzle to perform 3D linear fine-tuning, adjusting the relative position between the nozzle and the cell flow to ensure the sorting laser accurately irradiates target cells. At the same time, they drive the collection tube to move to the designated position for receiving sorted cells. Throughout the process, the displacement error must be ≤ 2 μm to avoid cell loss or sample mixing.

